Early T-cell precursor acute lymphoblastic leukaemia
نویسندگان
چکیده
منابع مشابه
Early T-cell Precursor Acute Lymphoblastic Leukemia/Lymphoma.
Discrete diagnostic subtypes of T lymphoblastic leukemia/lymphoma (T-cell acute lymphoblastic leukemia/lymphoma, T-ALL) have historically not been widely recognized. Recently, a novel subset with distinctive immunophenotypic, molecular, and clinical features has been proposed. Termed early T-cell precursor acute lymphoblastic leukemia (ETP-ALL), these cases seem to correspond to a very early st...
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Notch1 signalling is an essential event in the thymopoiesis. Activating Notch1 mutations are frequently seen in T-Acute Lymphoblastic Leukaemia (T-ALL). Notch1 is mainly involved in the T cell proliferation, differentiation and apoptosis. The mutations in the Notch1 have been reported in more than 50% of T-ALL cases. The aberrant Notch1 signalling has a prominent role in the biology of T-ALL. A...
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Infant T-cell acute lymphoblastic leukaemia (iT-ALL) is a very rare and poorly defined entity with a poor prognosis. We assembled a unique series of 13 infants with T-ALL, which allowed us to identify genotypic abnormalities and to investigate prenatal origins. Matched samples (diagnosis/remission) were analysed by single nucleotide polymorphism-array to identify genomic losses and gains. In th...
متن کاملMixed-phenotypic acute leukemia: cytochemically myeloid and phenotypically early T-cell precursor acute lymphoblastic leukemia
TO THE EDITOR: Early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) is characterized by the specific immunophenotype of CD1a, CD8, and CD5 with stem cell or myeloid marker expression. This leukemia presents a particular flow cytometric diagnostic challenge, as it frequently exhibits sufficient myeloid-lineage differentiation to be classified as mixed-phenotype acute leukemia (MPAL). Th...
متن کاملT-lymphoblastic leukaemia: a distinct variant of acute leukaemia.
Two cases of acute lymphoblastic leukaemia (A.L.L.) of T-cell type are reported. Clinically they were characterized by very high peripheral blood blast cell counts at presentation, the early development of meningeal leukaemia, and relative resistance to treatment with combination chemotherapy. Leukaemic cells from both patients lacked all the B-cell markers investigated, but 60-65% of their cel...
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ژورنال
عنوان ژورنال: Current Opinion in Hematology
سال: 2013
ISSN: 1065-6251
DOI: 10.1097/moh.0b013e3283623c61